姓名：范义辉
职称：教授
个人简介：江苏海门人，医学博士
专业研究领域：空间基因组学，医学基因组学，表观遗传学，肿瘤学，免疫治疗，自身免疫性疾病，基因功能，蛋白液-液相分离
专著与论集：
1. xu yp, wu yc, zhang sl, et al. a tumor specific super-enhancer drives immune evasion by guiding synchronous expression of pd-l1 and pd-l2. cell reports, 29 (11): 3435-3447 (2019).
2. wu yc, zhao jw, zhu hl, et al. space: a web server for linking chromatin accessibility with clinical phenotypes and the immune microenvironment in pan-cancer analysis. cellular & molecular immunology, 17（12）：1294 – 1296. （2020）
3. wu yc, yang y, gu hy, et al. international journal of cancer, 147(8):2210-2224. (2020)
4. guo cl, ni wk, ma pp, et al. the endoribonuclease n4bp1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.cell death and disease, 12(5):488. (2021).
5. fan zw, wu cy, chen mm, et al. the generation of pd-l1 and pd-l2 in cancer cells: from nuclear chromatin reorganization to extracellular presentation.acta pharmaceutica sinica b, 12(3):1041-1053.(2022)
6. xiao x #, fan yihui #, li j, et al. guidance of super-enhancers in regulation of il-9 induction and airway inflammation. journal of experimental medicine 215(2): 559 – 574 (2018).
7. xiao x#, shi xm #, fan yh#, et. ox40 inhibits th17 cells through activation of repressive chromatin remodeling pathways. immunity 44: 1271-1283 (2016).
8. fan yh, mao rf, yu y, et al.usp21 negatively regulates antiviral response by acting as a rig-i deubiquitinase. journal of experimental medicine211(2):313-328 (2014).
9. fan yh #, ge nl #, wang xs #, et al. amplification and over-expression of map3k3 gene in human breast cancer promotes formation and survival of breast cancer cells. journal of pathology 232(1):75-86 (2014).
10. fan yh, yu y, mao rf. usp4 targets tak1 to downregulate tnfa-induced nf-kb activation. cell death and differentiation, 18:1547-1560 (2011).
主要科研项目
主持多项省部级以上科研项目，其中包括国家自然科学基金项目4项，江苏省自然科学基金1项，江苏省特聘教授基金。
讲授课程
病原生物学，科研思维案例教学，病原生物学研究进展
指导研究生情况
已毕业博士研究生1名，硕士生7名；在读博士生2名，硕士生5名。
