姓名：顾建兰
职称：教授
个人简介：江苏南通人，医学博士。
专业研究领域：神经退行性疾病的病理机制及防治。
专著与论集：
1.yang m, qi r, liu y, shen x, zhao y, jin n, wu r, liu f*, gu j*. casein kinase 1δ phosphorylates tdp-43 and suppresses its function in tau mrna processing. j alzheimers dis. 2023;91(4):1527-1539.
2.wu r, zhou d, shen x, chen f, liu f*, gu j*. phosphorylation of trans-active response dna binding protein of 43 kda promotes its cytoplasmic aggregation and modulates its function in tau mrna stability and exon 10 alternative splicing. j neurochem. 2021 aug; 158(3):766-778.
3.gu j*, liu f. tau in alzheimer’s disease: pathological alterations and an attractive therapeutic target. curr med sci. 2020 dec;40(6):1009-1021.
4.gu j#, xu w#, jin n, li l, zhou y, chu d, gong cx, iqbal k, liu f*. truncation of tau selectively facilitates its pathological activities. j biol chem. 2020 oct 2;295(40):13812 -13828.
5.gu j, hu w, tan x, qu s, chu d, gong cx, iqbal k, liu f*. elevation of casein kinase 1ε is associated with tdp-43 and tau pathologies in alzheimer's disease. brain pathol. 2020 mar; 30(2): 283-297.
6.gu j*, chu d, jin n, chen f, liu f*. cyclic amp-dependent protein kinase phosphorylates tdp-43 and modulates its function in tau mrna processing. j alzheimers dis. 2019;70(4): 1093-1102.
主要科研项目
主持多项省部级以上科研项目，其中包括国家自然科学基金项目2项，江苏省自然科学基金项目1项。
讲授课程
生物化学与分子生物学
指导研究生情况
已毕业硕士生1名；在读硕士生2名。
